Cysteine protease inhibitors

Compounds of the formula (I) wherein R is H; and R is C-Calkyl, Carbocyclyl or Het; or R and R together define a saturated cyclic amine with 3-6 ring atoms; R and R are independently H, halo, C-Calkyl, C-Chaloalkyl or C-Calkoxy, or R and R together with the carbon atom to which they are attached for...

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Main Authors AYESA, SUSANA, CARLQUIST, PETER, KLASSON, BJORN, KAHNBERG, PIA, GRABOWSKA, URSZULA, HEWITT, ELLEN, WIKTELIUS, DANIEL, ERSMARK, KAROLINA, LIND, PETER, JONSSON, DANIEL, ODEN, LOURDES, PARKES, KEVIN
Format Patent
LanguageEnglish
Published 14.06.2012
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of the formula (I) wherein R is H; and R is C-Calkyl, Carbocyclyl or Het; or R and R together define a saturated cyclic amine with 3-6 ring atoms; R and R are independently H, halo, C-Calkyl, C-Chaloalkyl or C-Calkoxy, or R and R together with the carbon atom to which they are attached form a C-Ccycloalkyl; R is a branched C-C alkyl chain, C-Chaloalkyl or -CHC-C cycloalkyl; R is C-Calkyl, C-Chaloalkyl, C-Calkylamino or C-Cdialkylamino; for use in the prophylaxis or treatment of a disorder characterised by inappropriate expression or activation of cathepsin S.
Bibliography:Application Number: AU20100329470