Combretastatin derivative preparation method

The invention relates to a method for preparing a combretastatin derivative (I) or (II), said method including the following steps: triaryl(3,4,5-trimethoxybenzyl)phosphonium halide P (III), wherein Ar denotes an aryl group selected from among phenyl or thienyl, is reacted with P having formula (IV)...

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Bibliographic Details
Main Authors TREMAUDEUX, NICOLAS, DIDIER, ERIC, BESSE, PASCAL
Format Patent
LanguageEnglish
Published 21.06.2012
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a method for preparing a combretastatin derivative (I) or (II), said method including the following steps: triaryl(3,4,5-trimethoxybenzyl)phosphonium halide P (III), wherein Ar denotes an aryl group selected from among phenyl or thienyl, is reacted with P having formula (IV) or P' having formula (V) so as to respectively obtain the compound P or P', which have formulas (VI) and (VII), respectively; then, during a step for deprotection in the presence of an acid and/or a base, the compound having P or P' leads, after an optional purification step, to the compound having formula (I) or (II).
Bibliography:Application Number: AU20100326423