Analogues of insulin-like growth factor-1 (IGF-1) having amino acid substitution at position 59

The present invention relates to novel analogues of insulin-like growth factor- 1 (IGF- 1), pharmaceutical compositions containing said analogues, and the use of said analogues for treatment of IGF-1 -receptor mediated conditions, such as short stature, diabetes therapy, neurodegenerative disease tr...

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Bibliographic Details
Main Authors UFRET, MARIA L, ROTHMAN, DEBORAH, COMSTOCK, JEANNE MARY, ZHANG, JUNDONG, DONG, ZHENG XIN, PRAIRIE, NICHOLAS C
Format Patent
LanguageEnglish
Published 24.10.2013
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to novel analogues of insulin-like growth factor- 1 (IGF- 1), pharmaceutical compositions containing said analogues, and the use of said analogues for treatment of IGF-1 -receptor mediated conditions, such as short stature, diabetes therapy, neurodegenerative disease treatment, and cartilage repair. More particularly, the present invention relates to novel analogues of IGF-I having an amino acid substitution at position 59, e.g., (Asn
Bibliography:Application Number: AU20100275010