Antibodies that recognize sulphatides and sulphated proteoglycans and the use thereof

• Main Authors: BRITO NAVARRO, VICTOR, MATEO DE ACOSTA DEL RIO, CRISTINA MARIA, VAZQUEZ LOPEZ, ANA MARIA, FERNANDEZ MARRERO, YUNIEL, SOTO LOPEZ, YOSDEL, LOPEZ REQUENA, ALEJANDRO
• Format: Patent
• Language: English
• Published: 29.05.2014
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to the field of biotechnology and particularly to novel products for use in human health. The present invention provides novel monoclonal antibodies that specifically and with high affinity recognize sulphatides and sulphated proteoglycans. The anti-sulphatide and anti-sulphated proteoglycan antibodies described in the present specification constitute important diagnostic and therapeutic agents for acting on pathological processes associated with the appearance of atherosclerotic plaques. According thereto, the invention provides pharmaceutical compositions that comprise the monoclonal antibodies of the invention or fragments derived from these antibodies for therapeutic and diagnostic use in association with cardiovascular diseases. Additionally, the present invention relates to fragments of the monoclonal antibodies that recognize sulphatides and sulphated proteoglycans, such that said fragments may be used in the treatment or diagnosis of this pathological condition.