N4-phenyl-quinazoline-4 -amine derivatives and related compounds as ERBB type 1 receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases

This invention provides compounds of Formula (I), wherein B, G, A, E, R 1 , R 2 , R 3 , m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.

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Bibliographic Details
Main Authors QIAN ZHAO, FREDRIK P. MARMSATER, JOSEPH P. LYSSIKATOS, D. DAVID HENNINGS, JULIE MARIE GRESCHUK, WEIDONG LIU
Format Patent
LanguageEnglish
Published 01.07.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention provides compounds of Formula (I), wherein B, G, A, E, R 1 , R 2 , R 3 , m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.
Bibliography:Application Number: AU20100202330