Ultra high affinity neutralizing antibodies

ULTRA HIGH AFFINITY NEUTRALIZING ANTIBODIES Abstract Ultra high affinity antibodies with binding affinities in the range of 1010M', and even 101 M-' are disclosed. Such antibodies include antibodies having novel high affinity 5 complementarity determining regions (CDRs), especially those w...

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Bibliographic Details
Main Authors JOHNSON, LESLIE S, KOENIG, SCOTT, HUSE, WILLIAM D, YOUNG, JAMES F, WU, HERREN, WATKINS, JEFFRY D
Format Patent
LanguageEnglish
Published 17.05.2012
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:ULTRA HIGH AFFINITY NEUTRALIZING ANTIBODIES Abstract Ultra high affinity antibodies with binding affinities in the range of 1010M', and even 101 M-' are disclosed. Such antibodies include antibodies having novel high affinity 5 complementarity determining regions (CDRs), especially those with framework and constant regions derived from either humans or mice. Methods of preparing and screening such antibodies, as well as methods of using them to prevent and/or treat disease, especially virus-induced diseases, are also disclosed.
Bibliography:Application Number: AU20100201090