Modified Cpn10 and PRR signalling

The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to composit...

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Main Authors WARD, LINDA ALISSON, RALSTON, KEYLIE JANE, VAN HEUMEN, WALTER RENE ANTONIUS, JAMES, ANDREW LEIGH, HOWARD, CHRISTOPHER BRUCE, BROWN, RICHARD JAMES, STOK, JEANETTE ELIZABETH, NAYLOR, DEAN JASON, LAMBERT, DANIEL SCOTT, DE BAKKER, CHRISTOPHER JOHN
Format Patent
LanguageEnglish
Published 02.10.2014
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to isolated Cpn10 polypeptides possessing an increased affinity for a PRR ligand compared to Ala Cpn10 polypeptide. In a further embodiment, the present invention also relates to modified chaperonin 10 polypeptides, and to nucleic acids encoding the same and to compositions comprising such polypeptides and uses thereof.
Bibliography:Application Number: AU20090235953