Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase

Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, an...

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Main Authors EUGENE Y. CHEUNG, ALVAH T. WICKBOLDT, DIEGO BROGGINI, ANNE M. FOURINE, LAURENT GOMEZ, GENESIS M. BACANI, XIAOHU DENG, HARTMUT ZINSER, CHRISTA C. CHROVIAN, JIMMY T. LIANG, VIRGINIA M. TANIS, AARON M. KEARNEY, KATHLEEN C. SAPPEY, SUSANNE LOCHNER, JOHN, J.M. WIENER, KIA SEPASSI, ALEJANDRO SANTILLAN JR, NEELAKANDHA S. MANI, CHERYL A. GRICE, ADRIENNE M. LANDRY-BAYLE, ALICE LEE-DUTRA
Format Patent
LanguageEnglish
Published 15.10.2009
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
Bibliography:Application Number: AU20090234140