Optical method for determining morphological parameters and physiological properties of tissue

• Main Authors: STAMNES, KNUT, ZHAO, LU, MOAN, JOHAN E, SOMMERSTEN, ENDRE R, HAMRE, BOERGE, STAMNES, JAKOB J, BIRYULINA, MARINA, NIELSEN, KRISTIAN P, RYZHIKOV, GENNADY
• Format: Patent
• Language: English
• Published: 10.07.2014
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

In an embodiment of the present disclosure, an optical method for determining morphological parameters and physiological properties of tissue is presented. The method includes using reflectance measurements from a tissue area for a plurality of wavelengths, using a bio-optical model, using radiative transfer modeling and using a non-linear inversion procedure. The method further includes systematically varying values of the morphological parameters and physiological properties of the tissue and simultaneously varying the inherent optical properties, which are linked to the morphological parameters and the physiological properties of the tissue, until the non-linear inversion procedure returns values for the morphological parameters and the physiological properties of the tissue such that an agreement between the reflectance measurements and reflectances computed by the radiative transfer model, based on the returned morphological parameters and the physiological properties of the tissue values and corresponding inherent optical properties values, reach a predetermined level of accuracy.