Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics

This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KIAA0746, CD20 or CD55 antigens, which are differentially expressed in cancer and in specific blood...

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Bibliographic Details
Main Authors YARON KINAR, SHIRLEY SAMEACH-GREENWALD, ANAT COHEN-DAYAG, EVE MONTIA, ZURIT LEVIN, GALIT ROTMAN, SERGEY NEMZAR, SHIRA WALACH, AMIR TOPORIK, AVI YESHAH ROSENBERG, MERAV BEIMAN, LIAT DASSA, OFER LEVY
Format Patent
LanguageEnglish
Published 06.08.2009
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KIAA0746, CD20 or CD55 antigens, which are differentially expressed in cancer and in specific blood cells, and diagnostic and therapeutic usages. This invention further relates to the discovery of extracellular domains of KIAA0746 and its variants, CD20 and its variants, CD55 and its variants, which are suitable targets for immunotherapy, cancer therapy, treatment of inflammatory, allergic and autoimmune disorders, and drug development.
Bibliography:Application Number: AU20090208607