Novel synthesis of beta-nucleosides
This invention relates to a process of stereoselectively synthesizing a -nucleoside compound of formula (I): wherein R1, R2, and B are as defined in the specification; each of R3 and R4, independently, is H or fluoro. The process includes reacting, in the presence of a transition metal salt, a tetra...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English |
| Published |
14.05.2009
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| Subjects | |
| Online Access | Get full text |
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| Abstract | This invention relates to a process of stereoselectively synthesizing a -nucleoside compound of formula (I): wherein R1, R2, and B are as defined in the specification; each of R3 and R4, independently, is H or fluoro. The process includes reacting, in the presence of a transition metal salt, a tetrahydrofuran compound of formula (II): wherein R1, R2, and L are as defined in the specification, with a nucleobase derivative; and each of R3 and R4, independently, is H or fluoro. |
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| AbstractList | This invention relates to a process of stereoselectively synthesizing a -nucleoside compound of formula (I): wherein R1, R2, and B are as defined in the specification; each of R3 and R4, independently, is H or fluoro. The process includes reacting, in the presence of a transition metal salt, a tetrahydrofuran compound of formula (II): wherein R1, R2, and L are as defined in the specification, with a nucleobase derivative; and each of R3 and R4, independently, is H or fluoro. |
| Author | WENSEN LI CHI-YUAN CHU CHAN KOU HWANG WEI-DER LEE |
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| Snippet | This invention relates to a process of stereoselectively synthesizing a -nucleoside compound of formula (I): wherein R1, R2, and B are as defined in the... |
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| Title | Novel synthesis of beta-nucleosides |
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