Novel synthesis of beta-nucleosides

This invention relates to a process of stereoselectively synthesizing a -nucleoside compound of formula (I): wherein R1, R2, and B are as defined in the specification; each of R3 and R4, independently, is H or fluoro. The process includes reacting, in the presence of a transition metal salt, a tetra...

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Bibliographic Details
Main Authors CHI-YUAN CHU, WEI-DER LEE, WENSEN LI, CHAN KOU HWANG
Format Patent
LanguageEnglish
Published 14.05.2009
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:This invention relates to a process of stereoselectively synthesizing a -nucleoside compound of formula (I): wherein R1, R2, and B are as defined in the specification; each of R3 and R4, independently, is H or fluoro. The process includes reacting, in the presence of a transition metal salt, a tetrahydrofuran compound of formula (II): wherein R1, R2, and L are as defined in the specification, with a nucleobase derivative; and each of R3 and R4, independently, is H or fluoro.
Bibliography:Application Number: AU20080323923