Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof

The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The invention provides compositions of prokary...

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Bibliographic Details
Main Authors DANIEL J. WENDT, MUBARACK MUTHALIF, PAUL A. FITZPATRICK, AUGUSTUS O. OKHAMAFE, SEAN M. BELL, MICHEL C. VELLARD, EMIL D. KAKKIS
Format Patent
LanguageEnglish
Published 26.02.2009
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or a reduced immunogenicity as compared to a wild-type PAL. The invention provides compositions of prokaryotic PAL and biologically active fragments, mutants, variants or analogs thereof, as well as methods for the production, purification, and use of such compositions for therapeutic purposes, including the treatment of cancer.
Bibliography:Application Number: AU20080289549