Single-domain antigen-binding proteins that bind mammalian IgG

The present invention relates to antigen-binding proteins that are capable of binding to mammalian IgG. The frame-work regions of the antigen-binding proteins of the invention preferably correspond to those of antibodies naturally that are devoid of light chains as may e.g. be found in camelids. The...

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Bibliographic Details
Main Authors WILHELMUS JOSEPHUS JOHANNA HERMANS, SANDRA BEZEMER, YVONNE MATHALIE MIJNSBERGEN
Format Patent
LanguageEnglish
Published 22.01.2009
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to antigen-binding proteins that are capable of binding to mammalian IgG. The frame-work regions of the antigen-binding proteins of the invention preferably correspond to those of antibodies naturally that are devoid of light chains as may e.g. be found in camelids. The invention further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, to the uses of such immunoadsorbent materials for the purification of mammalian IgG antibodies and for therapeutic apheresis.
Bibliography:Application Number: AU20080276787