Inhibitors of janus kinases

The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administe...

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Main Authors HAIDLE, ANDREW, SIU, TONY, ZABIEREK, ANNA, WOO, HYUN CHONG, GRIMM, JONATHAN B, TEMPEST, PAUL, WILSON, KEVIN, MACCOSS, RACHEL N, TAOKA, BRANDON, YOUNG, JONATHAN, MACHACEK, MICHELLE, ALTMAN, MICHAEL, OTTE, RYAN D, KONRAD, KALEEN, OSIMBONI, EKUNDAYO, CHRISTOPHER, MATTHEW, LIM, JONGWON, SPENCER, KERRIE
Format Patent
LanguageEnglish
Published 30.01.2014
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
CHEMISTRY
FISHING
FORESTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
TRAPPING
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Summary:The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
Bibliography:Application Number: AU20080266883