Nitrogenated fused ring derivative, pharmaceutical composition comprising the same, and use of the same for medical purposes

• Main Authors: OHNO, KOHSUKE, FUSHIMI, NOBUHIKO, KAMBARA, MIKIE, YONEKUBO, SHIGERU, MIYAGI, TAKASHI
• Format: Patent
• Language: English
• Published: 01.11.2012
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

[PROBLEMS] To provide a compound useful as a prophylactic or therapeutic agent for a sex hormone-dependent disease or the like. [MEANS FOR SOLVING PROBLEMS] Disclosed are: a nitrogenated fused ring derivative represented by the general formula (I), or a prodrug, salt or the like thereof, which has a GnRH antagonistic activity; a pharmaceutical composition comprising the derivative or the prodrug, salt or the like thereof; use of the the derivative or the prodrug, salt or the like thereof for medical purposes; and others. In the general formula (I), the rings A and B independently represent an aryl or a heteroaryl; R and R independently represent a halogen, a cyano, an alkyl, an alkylsulfonyl, -OW, -SW, -COW, -NWW, -SONWW, an aryl or the like; R represents H or an alkyl; E represents an oxygen atom or the like; U represetns a single bond or an alkylene; and X represents Y, -CO-Y, -SO-Y, -S-(alkylene)-Y, -O-(alkylene)-Y, -SO-(alkylene)-Y or the like [wherein Y represents Z, an amino or the like; and Z represents a cycloalkyl, a heterocycloalkyl, an aryl, a heteroaryl or the like].