Method for determining the amount of conjugated taxane in polyglut acid-taxane conjugates

The invention relates to a method for determining the amount of conjugated taxane, in particular paclitaxel, in a PGA-taxane conjugate said method comprising: a) reacting the PGA-taxane conjugate with a compound formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ R 1 R 2 N-NH 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I) wherein R 1 and R 2 are as de...

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Bibliographic Details
Main Authors MARC MCKENNON, STEFANO FAZIONI, KEITH HOVDA, HOLLY SPOONEMORE, VALERIA LIVI, LUIGI SIVIERO
Format Patent
LanguageEnglish
Published 12.09.2008
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:The invention relates to a method for determining the amount of conjugated taxane, in particular paclitaxel, in a PGA-taxane conjugate said method comprising: a) reacting the PGA-taxane conjugate with a compound formula (I): €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ R 1 R 2 N-NH 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I) wherein R 1 and R 2 are as defined in the description; to give a unbound taxane and a PGA hydrazide and b) determining the amount of unbound taxane.
Bibliography:Application Number: AU20080224139