Optimized CD40 antibodies and methods of using the same

The present invention describes antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcyR or alters effector function as compared to the parent antibody. Also disclosed are methods of usin...

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Bibliographic Details
Main Authors KARKI, SHER BAHADUR, LAZAR, GREGORY ALAN, ZHUKOVSKY, EUGENE ALEXANDER, BERNETT, MATTHEW J, CHU, SEUNG YUP, DESJARLAIS, JOHN R, PONG, ERIK WEIKING
Format Patent
LanguageEnglish
Published 03.05.2012
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention describes antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcyR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.
Bibliography:Application Number: AU20080207898