Pyrido (2, 3-D) pyrimidin0ne compounds and their use as PI3 inhibitors

The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-Kalpha).

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Main Authors DILIP BHUMRALKAR, ROBERT STEVEN KANIA, MICHELL DAVID NAMBU, MICHAEL BRUNO PLEWE, MARY CATHERINE JOHNSON, MASON ALAN PAIRISH, PHUONG THI QUY LE, KHANH TUAN TRAN, KLAUS RUPRECHT DRESS, JACQUI ELIZABET HOFFMAN, HENGMIAO CHENG
Format Patent
LanguageEnglish
Published 20.03.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-Kalpha).
AbstractList The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-Kalpha).
Author KLAUS RUPRECHT DRESS
JACQUI ELIZABET HOFFMAN
HENGMIAO CHENG
PHUONG THI QUY LE
ROBERT STEVEN KANIA
DILIP BHUMRALKAR
MARY CATHERINE JOHNSON
MICHELL DAVID NAMBU
MASON ALAN PAIRISH
MICHAEL BRUNO PLEWE
KHANH TUAN TRAN
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– fullname: MICHAEL BRUNO PLEWE
– fullname: MARY CATHERINE JOHNSON
– fullname: MASON ALAN PAIRISH
– fullname: PHUONG THI QUY LE
– fullname: KHANH TUAN TRAN
– fullname: KLAUS RUPRECHT DRESS
– fullname: JACQUI ELIZABET HOFFMAN
– fullname: HENGMIAO CHENG
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Snippet The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Pyrido (2, 3-D) pyrimidin0ne compounds and their use as PI3 inhibitors
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