Pyrido (2, 3-D) pyrimidin0ne compounds and their use as PI3 inhibitors

The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-Kalpha).

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Bibliographic Details
Main Authors DILIP BHUMRALKAR, ROBERT STEVEN KANIA, MICHELL DAVID NAMBU, MICHAEL BRUNO PLEWE, MARY CATHERINE JOHNSON, MASON ALAN PAIRISH, PHUONG THI QUY LE, KHANH TUAN TRAN, KLAUS RUPRECHT DRESS, JACQUI ELIZABET HOFFMAN, HENGMIAO CHENG
Format Patent
LanguageEnglish
Published 20.03.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-Kalpha).
Bibliography:Application Number: AU20070297212