Antifungal agents

The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)- -D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compos...

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Bibliographic Details
Main Authors JAMES M. BALKOVEC, FRANCES AILEEN BOUFFARD, MICHAEL PEEL, WEIMING FAN, MARK L. GREENLEE, HAO LIU, AHMED MAMAI, DONGFANG MENG, BRUNO TSE, KEQAING LI, JAMES DROPINSKI
Format Patent
LanguageEnglish
Published 08.11.2007
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)- -D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.
Bibliography:Application Number: AU20070245024