Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith

Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condit...

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Main Authors ELISE SUDBECK, MARIANNE K. SLOSS, KIRAN SAHASRAMUDHE, MOORTHY S.S. PALANKI, JOHN SAPIENZA, LISA NADOLNY, ADAM KOIS, MARIA MERCEDES DELGADO MEDEROS, STEVEN S. CLAREEN, JONATHAN WRIGHT, YOSHITAKA SATOH, LETICIA AYALA, MEG MCCARRICK, RONALD J. ALBERS, KEVIN HUGHES, VERONIQUE PLANTEVIN-KRENITSKY, ROBERT HILGRAF, SAYEE G. HEGDE
Format Patent
LanguageEnglish
Published 08.11.2007
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
Bibliography:Application Number: AU20070243287