Crystal form of besipirdine chlorhydrate, process preparation and use thereof

Crystalline besipirdine hydrogen chloride (I) having physicochemical properties i.e.: in Fourier transform infrared spectroscopy has absorption bands at 778, 1198, and 1121 cm -> 1> with +-5 cm -> 1> and does not show absorption bands at 3395, 1583 and 732 cm -> 1> with +-5 cm ->...

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Bibliographic Details
Main Authors HUGUES BIENAYME, JACQUES FERTE
Format Patent
LanguageEnglish
Published 30.08.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Crystalline besipirdine hydrogen chloride (I) having physicochemical properties i.e.: in Fourier transform infrared spectroscopy has absorption bands at 778, 1198, and 1121 cm -> 1> with +-5 cm -> 1> and does not show absorption bands at 3395, 1583 and 732 cm -> 1> with +-5 cm -> 1>; in X-ray powder diffraction has diffraction lines of 12.61, 14.11, 18.98, 19.93, 21.03, 25.13 and 25.91 2tau with a corresponding intensity of 77.13, 71.82, 73, 67.21, 61.08, 60.44 and 100%; in differential scanning calorimetry has an endothermic peak at 185.3-189.3[deg]C, and an enthalpy of fusion of 128.4-132.4 J/g, is new. Independent claims are included for: (1) the preparation methods of (I); and (2) a therapeutic composition comprising (I) at 90%. ACTIVITY : Uropathic; Antiinflammatory. MECHANISM OF ACTION : None given.
Bibliography:Application Number: AU20070219157