Substituted benzimidazoles and methods of preparation

New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine k...

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Bibliographic Details
Main Authors BRIAN DIAZ, DAVID RYCKMAN, DAVID A. SIESEL, BRADY S. STILLWELL, DANIEL J. POON, JONATHAN P. VAN DYCK, DANLIN GU, MARTIN DIMITROFF, TERESA E. PICK, TYSON SWIFTNEY, BRIDGET R. MILLER
Format Patent
LanguageEnglish
Published 28.04.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:New substituted benzimidazole compounds, compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
Bibliography:Application Number: AU20060284666