Macrocyclic inhibitors of hepatitis C virus

• Main Authors: WAHLING, HORST JURGEN, RABOISSON, PIERRE JEAN-MARIE BERNARD, DE KOCK, HERMAN AUGUSTINUS, KAHNBERG, PIA CECILIA, SAHLBERG, SVEN CRISTER, BELFRAGE, ANNA KARIN GERTRUD LINNEA, ROSENQUIST, ASA ANNICA KRISTINA, WALLBERG, HANS KRISTIAN, SAMUELSSON, BENGT BERTIL, CLASSON, BJORN OLOF, HU, LILI, LINDQUIST, KARIN CHARLOTTA, LINDSTROM, MATS STEFAN, NILSSON, KARL MAGNUS, SIMMEN, KENNETH ALAN
• Format: Patent
• Language: English
• Published: 12.04.2012
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds of the formula (I), and N-oxides, salts, and stereoisomers thereof wherein A is OR, NHS(=O)R; wherein; R is hydrogen, C-Calkyl, C-Calkylenecarbocyclyl, C-Calkylene-heterocyclyl; R is C-Calkyl, C-Calkylenecarbocyclyl, C-Calkyleneheterocyclyl; p is independently 1 or 2; n is 3, 4, 5 or 6; --- deonotes an optional double bond; L is N or CRz; Rz is H or forms a double bond with the asterisked carbon; Rq is H or when L is CRz, Rq can also be C-Calkyl; Rr is quinazolinyl, optionally substituted with one two or three substituents each independently selected from C-C alkyl, C-Calkoxy, hydroxyl, halo, haloC-Calkyl, amino, mono- or dialkylamino, mono- or dialkylaminocarbonyl, C-Calkyl- carbonylamino, C-Calkylenecarbocyclyl and C-C alkyleneheterocyclyl; R is hydrogen, C-Calkyl, C-CalkoxyC-Calkyl or C-Ccycloalkyl; R is hydrogen, C-Calkyl, C-Calkoxy, C-Calkylenecarbocyclyl, C-Calkyleneheterocyclyl, hydroxy, bromo, chloro or fluoro have utility in the treatment or prophylaxis of flaviviral infections such as HCV.