DNA-PK inhibitors

Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N; and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C( O), CH2 and NH are disclosed for use in...

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Main Authors NIALL MORRISON BARR MARTIN, DAVID RICHARD NEWELL, MARK FRIGERIO, KAPPUSAMY SARAVANAN, BERNARD THOMAS GOLDING, HILARY ALAN CALVERT, XIAO-LING FAN COCKCROFT, GRAEME CAMERON MURRAY SMITH, NICOLA JANE CURTIN, MARINE DESAGE-EL MURR, ROGER JOHN GRIFFIN, MARC GEOFFREY HUMMERSONE, KEITH ALLAN MENEAR, IAN ROBERT HARDCASTLE
Format Patent
LanguageEnglish
Published 19.10.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N; and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C( O), CH2 and NH are disclosed for use in inhibiting DNA-PK.
Bibliography:Application Number: AU20060235731