Cyclic amine derivative or salt thereof

Provided are compounds which are an NMDA antagonist having a broad safety margin and are useful as a treating agent or a preventing agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, pain, etc. Concretely provided are an amine derivative or its...

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Main Authors TAKAHIKO TOBE, NOBUYUKI SHIRAISHI, SHINGO YAMASAKI, YOSHITSUGU SHITAKA, TAKATOSHI KANAYAMA, KYOICHI MAENO, SATOSHI HAYASHIBE, SHIGEKI KAWABATA, HIROAKI HOSHII, JOTAROU SUZUKI, JUNYA OHMORI, DAISUKE SUZUKI
Format Patent
LanguageEnglish
Published 30.03.2006
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Provided are compounds which are an NMDA antagonist having a broad safety margin and are useful as a treating agent or a preventing agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, pain, etc. Concretely provided are an amine derivative or its salt characterized in that the amine-containing structure A therein bonds to a 2- or 3-cyclic condensed ring (e.g., indane, tetralone, 4,5,6,7-tetrahydrobenzothiophene, 4,5,6,7-tetrahydrobenzofuran, 7,8-dihydro-6H-indeno[4,5-b]furan, 2,3-dihydro-1H-cyclopenta[1]naphthalene) via X 1 (bond or lower alkylene); and an NMDA antagonist containing it as an active ingredient thereof.
Bibliography:Application Number: AU20050285878