Polycyclic pyrazines as potassium ion channel modulators

The present invention provides a genus of polycyclic pyrazines of formula (I): wherein A and B are independently substituted or unsubstituted 5- or 6- membered heterocycloalkyl, or substituted or unsubstituted 5- or 6- membered heteroaryl, W1 is W2is -CH-, -NH-, -N-, -S-, or -O-; Z1 is Z2 is -CH-, -...

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Bibliographic Details
Main Authors KERRY LEIGH SPEAR, AYAKO MORITOMO, XIAODONG WANG, ALAN BRADLEY FULP, TAKAHIRO ISHII, DARRICK SECONI, TAKESHI SUZUKI
Format Patent
LanguageEnglish
Published 22.12.2005
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a genus of polycyclic pyrazines of formula (I): wherein A and B are independently substituted or unsubstituted 5- or 6- membered heterocycloalkyl, or substituted or unsubstituted 5- or 6- membered heteroaryl, W1 is W2is -CH-, -NH-, -N-, -S-, or -O-; Z1 is Z2 is -CH-, -NH-, -N-, -S-, or -O-; Y is a bond, -CH-N-NH-, -NH-CH2, or -NR5-; s and t are independently integers from 1 to 4; and the substituents R1, R2A, R2B and R3 are as defined in the specification for compounds of formula (I). The polycyclic pyrazine compounds are useful as modulators of potassium ion channels in both therapeutic and diagnostic methods.
Bibliography:Application Number: AU20050252160