Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients
The present invention relates to a method to obtain an expression score to evaluate gene expression in a tissue specimen obtained from a person having or suspected of having cancer comprising: a) determining by immunohistochemistry a fraction score, wherein the fraction score corresponds to the perc...
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Main Authors | , , , , |
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Format | Patent |
Language | English |
Published |
15.12.2005
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to a method to obtain an expression score to evaluate gene expression in a tissue specimen obtained from a person having or suspected of having cancer comprising:
a) determining by immunohistochemistry a fraction score, wherein the fraction score corresponds to the percentage of cells in the tissue specimen that stain positive for a biomarker;
b) determining an intensity score that corresponds to the staining intensity of the biomarker in the sample of tumor cells;
c) calculating an expression score that is a numerical evaluation of the product of the fraction score and the intensity score. |
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Bibliography: | Application Number: AU20050249492 |