Processes and intermediates for preparing anti-cancer compounds

• Main Authors: TIMOTHY NORRIS, RICHARD SHELTON LEHNER, DINOS PAUL SANTAFIANOS
• Format: Patent
• Language: English
• Published: 07.02.2008
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; AGRICULTURE; ANIMAL HUSBANDRY; APPARATUS THEREFOR; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FERROUS OR NON-FERROUS ALLOYS; FISHING; FORESTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; PRETREATMENT OF RAW MATERIALS; PRODUCTION AND REFINING OF METALS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING; TREATMENT OF ALLOYS OR NON-FERROUS METALS

The present invention relates to methods and intermediates for preparing compounds of the formula 1 and the pharmaceutically acceptable salts and solvates thereof, as well as structurally related compounds, wherein R , R and R are as defined herein. The foregoing compounds are useful in the treatment of hyperproliferative disorders, such as cancers, in mammals. The present invention also relates to a method of preparing compounds of the formula 9 and the pharmaceutically acceptable salts and solvates thereof, wherein R -R and R are as defined herein.