Method and compositions for identifying anti-HIV therapeutic compounds

• Main Authors: MARCOS HATADA, MICHAEL L. MITCHELL, CHRISTOPHER P. LEE, MARK M. BECKER, MARK SPARACINO, RICHARD L. MACKMAN, SUNDARAMOORTHI SWAMINATHAN, JIANYING WANG, AZAR DASTGAH, MARIA FARDIS, JAMES M. CHEN, GABRIEL BIRKUS, XIAOWU CHEN, JAMES D. TARIO, TOMAS CIHLAR, MARTIN J. MCDERMOTT, MURTY N. ARIMILLI, RICHARD H. YU, WILLIAM A. LEE, CHOUNG U. KIM, LIANHONG XU, GONG-XIN HE, TANISHA D. ROWE, KUEI-YING LIN, MATTHEW A. WILLIAMS, EUGENE J. EISENBERG, LIJUN ZHANG, JIANCUN ZHANG, ZHENG-YU YANG, HAOLUN JIN, HONGTAO LIU, CLIFFORD BRYANT, HYUNG-JUNG PYUN, PETER H. NELSON
• Format: Patent
• Language: English
• Published: 14.07.2005
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.