8-chloro-2,3-benzodiazepine derivatives

The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula -NH-R′, wherein R′ stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts th...

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Main Authors GABOR SZENASI, JOZSEF BARKOCZY, LASZLO GABOR HARSING, GABOR GIGLER, GYULA SIMIG, GYULA SZUCS, GEZA SZABO, ISTVAN LING, SZABOLCS KERTESZ, MIKLOS VEGH
Format Patent
LanguageEnglish
Published 17.12.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula -NH-R′, wherein R′ stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives. The compounds according to the invention possess AMPA/kainate receptor inhibiting activity.
Bibliography:Application Number: AU20040261491