TETRACYCLIC IMMUNOMODULATORY COMPOUNDS

The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes,...

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Main Authors MUHAMMED, KAMAL UDDIN, DORTHE DA GRACA THRIGE, FILIPPO MAGARACI, CHRIS, JAMES BRENNAN, LARS, OLOF, GORAN PETTERSSON, IAN, RICHARD MATTHEWS, PHILIP HUXLEY
Format Patent
LanguageEnglish
Published 09.07.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthritis, multiple sclerosis, diabetes, asthma, transplantation, systemic lupus erythematosis and psoriasis. More particularly, the present invention relates to novel heterocyclic compounds, which are CD80 antagonists capable of inhibiting the interactions between CD80 and CD28.
Bibliography:Application Number: AU20030287129