Method for producing solid galenic formulations using a crosslinked non-thermoplastic carrier

Production of a solid dosage form (A) involves: (1) forming a shapable mass comprising (by weight) 50-99.4% crosslinked, non-thermoplastic carrier (I), 0.5-30 wt. % adjuvant(s) (II) selected from thermoplastic polymers, lipids, sugar alcohols (or derivatives) and solubilizers and 0.1-49.5% active ag...

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Bibliographic Details
Main Authors MARKUS MAGERLEIN, JORG ROSENBERG, GUNTHER BERNDL
Format Patent
LanguageEnglish
Published 15.05.2008
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Production of a solid dosage form (A) involves: (1) forming a shapable mass comprising (by weight) 50-99.4% crosslinked, non-thermoplastic carrier (I), 0.5-30 wt. % adjuvant(s) (II) selected from thermoplastic polymers, lipids, sugar alcohols (or derivatives) and solubilizers and 0.1-49.5% active agent(s) (III) at or above the softening point of (II) (but at 70 degrees C or more); and (2) cooling.
Bibliography:Application Number: AU20030283261