Process for the preparation of 9-beta-anomeric nucleoside analogs

A process for substantially enhancing the regio and stereoselective synthesis of 9-beta-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base was preformed so that only the 9-beta-D- or L-purine nucleoside analogs were obtained. This regio an...

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Main Authors PRANAB K. GUPTA, STEPHEN A. MUNK
Format Patent
LanguageEnglish
Published 26.04.2007
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Abstract A process for substantially enhancing the regio and stereoselective synthesis of 9-beta-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base was preformed so that only the 9-beta-D- or L-purine nucleoside analogs were obtained. This regio and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs and in particular 2'-deoxy, 3'-deoxy, 2'-deoxy-2'-beta-fluoro and 2',3'-dideoxy-2'-beta-fluoro purine nucleoside analogs in high yield without virtually any formation of the 7-positional isomers. The compounds are drugs or intermediates to drugs.
AbstractList A process for substantially enhancing the regio and stereoselective synthesis of 9-beta-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base was preformed so that only the 9-beta-D- or L-purine nucleoside analogs were obtained. This regio and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs and in particular 2'-deoxy, 3'-deoxy, 2'-deoxy-2'-beta-fluoro and 2',3'-dideoxy-2'-beta-fluoro purine nucleoside analogs in high yield without virtually any formation of the 7-positional isomers. The compounds are drugs or intermediates to drugs.
Author PRANAB K. GUPTA
STEPHEN A. MUNK
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Snippet A process for substantially enhancing the regio and stereoselective synthesis of 9-beta-anomeric nucleoside analogs is described. The introduction of the sugar...
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SubjectTerms CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
Title Process for the preparation of 9-beta-anomeric nucleoside analogs
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