Process for the preparation of 9-beta-anomeric nucleoside analogs

A process for substantially enhancing the regio and stereoselective synthesis of 9-beta-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base was preformed so that only the 9-beta-D- or L-purine nucleoside analogs were obtained. This regio an...

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Bibliographic Details
Main Authors PRANAB K. GUPTA, STEPHEN A. MUNK
Format Patent
LanguageEnglish
Published 26.04.2007
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:A process for substantially enhancing the regio and stereoselective synthesis of 9-beta-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base was preformed so that only the 9-beta-D- or L-purine nucleoside analogs were obtained. This regio and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs and in particular 2'-deoxy, 3'-deoxy, 2'-deoxy-2'-beta-fluoro and 2',3'-dideoxy-2'-beta-fluoro purine nucleoside analogs in high yield without virtually any formation of the 7-positional isomers. The compounds are drugs or intermediates to drugs.
Bibliography:Application Number: AU20030251936