Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors

This invention pertains to certain carbamic acid compounds which inhibit HDAC (histone deacetylase) activity of the following formula: The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vi...

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Bibliographic Details
Main Authors CLARE J. WATKINS, PAUL W. FINN, JAMES RITCHIE, IGOR STARCHENKOV, KLARA DIKOVSKA, EINARS LOZA, KALVINSH IVARS, VIJA GAILITE, MARIA-ROSARIO ROMERO-MARTIN, DAINA LOLYA
Format Patent
LanguageEnglish
Published 11.06.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention pertains to certain carbamic acid compounds which inhibit HDAC (histone deacetylase) activity of the following formula: The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, etc.
Bibliography:Application Number: AU20030229883