ANTI-BACTERIAL AGENTS

• Main Authors: FAITH, ADELAIDE BURDEN, MARK, EDWARD RAPSON, DAVID, ALLAN HODGSON, LIUDMILLA, PENCHEVA GLANCEY, NICHOLAS, HAROLD MANN
• Format: Patent
• Language: English
• Published: 08.10.2003
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

A panel of bacteriophages comprising a first vir mutant bacteriophage capable of infecting and lysing a first strain of bacteria, and a second vir mutant capable of infecting and lysing a second strain of bacteria. A pharmaceutical composition including a panel of bacteriophages disclosed above. A method of identifying a bacteriophage suitable for killing a bacterium by obtaining a sample of the bacterium from a patient or site infected with the bacterium, identifying one or more phage sensitivity characteristics of the bacterium, comparing the characteristics from the identification step with the known host range of each library of bacteriophages, the library of bacteriophages including a first vir mutant bacteriophage capable of infecting and lysing a first strain of bacteria, and a second vir mutant capable of infecting and lysing a second strain of bacteria, and identifying one or more bacteriophages from the panel suitable for killing the bacterium.