QUINAZOLINEDIONE DERIVATIVES

A compound of formula (1): wherein: X and Y, which may be the same or different, is each an O or S atom; R is an aliphatic, cylcoaliphatic or cycloalkyl-akyl-group; R is an optionally substituted heteroaromatic group; R is the group Alk -L -Alk -R in which Alk is a covalent bond or an optionally sub...

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Bibliographic Details
Main Authors ANDREW SHARPE, ALAN, FINDLAY HAUGHAN, HAZEL, JOAN DYKE, MARIANNA, DILANI RICHARD
Format Patent
LanguageEnglish
Published 09.07.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound of formula (1): wherein: X and Y, which may be the same or different, is each an O or S atom; R is an aliphatic, cylcoaliphatic or cycloalkyl-akyl-group; R is an optionally substituted heteroaromatic group; R is the group Alk -L -Alk -R in which Alk is a covalent bond or an optionally substituted aliphatic or heteroaliphatic chain, L is a covalent bond or a linker atom or group, Alk is a covalent bond or an optionally substituted aliphatic or thereoaliphatic chain and R is a hydrogen atom or an optionally substituted cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates, tautomers, isomers or N-oxides thereof. The compounds of the present invention are potent inhibitors of IMPDH.
Bibliography:Application Number: AU20020352444