Water-soluble phenylpyridazine derivatives and medicines containing the same

Compounds having the formula (1): wherein R represents an alkyl or alkenyl group, R and R each independently represents a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl group, or R and R may be fused together with the adjacent nitrogen atom to form a substituted or unsubstituted,...

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Main Authors KYOKO YASUOKA, SEIICHI SATO, JUNKO TOTSUKA, SHUNJI TAKEMURA, HIROMICHI SHIGYO, YOSHINORI KYOTANI, TAKAHIRO KITAMURA, HIDEO YOSHIZAKI, TOMOYUKI KOSHI
Format Patent
LanguageEnglish
Published 18.10.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds having the formula (1): wherein R represents an alkyl or alkenyl group, R and R each independently represents a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl group, or R and R may be fused together with the adjacent nitrogen atom to form a substituted or unsubstituted, nitrogen-containing, saturated heterocyclic group, X, Y and Z each independently represents a hydrogen atom, an alkyl group, a halogen atom or the like, and n stands for an integer of from 1 to 5; and also to pharmaceutical compositions containing them. These compounds have inhibitory activity against IL-1 beta production, high water solubility and good oral absorbability.
Bibliography:Application Number: AU20020332286