Non-steroidal estrogen receptor ligands

Novel non-steroidal estrogen receptor ligands and methods of synthesis are disclosed. The novel molecules are intended for use in therapeutic preparations for the treatment of estrogen receptor related disease states. The compounds specified are tetra-cyclic derivatives and have been shown to be ant...

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Bibliographic Details
Main Authors JEFFRY LAWRENCE LOWELL, JOHN WHELAN, STEFAN KWIATKOWSKI, JULIE MERCURE, NATALIE LAZAROWYCH, KRZYSZTOF PUPEK, JONATHAN MARTIN SCHMIDT, SHUGUANG ZHU
Format Patent
LanguageEnglish
Published 04.09.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel non-steroidal estrogen receptor ligands and methods of synthesis are disclosed. The novel molecules are intended for use in therapeutic preparations for the treatment of estrogen receptor related disease states. The compounds specified are tetra-cyclic derivatives and have been shown to be antiproliferative against human estrogen-dependent cancer cells and to have good binding affinity for the estrogen receptor.
Bibliography:Application Number: AU20020238314