NOVEL 3-FUSED PYRIDINIUMMETHYL CEPHALOSPORINS

Novel semi-synthetic cephalosporin derivatives having a fused pyridiniummethyl at 3-position of the cephem nucleus, pharmaceutically acceptable salts, physiologically hydrolizable esters or solvates thereof are disclosed. Also disclosed is a process for preparing the cephalosporin derivatives which...

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Main Authors KOUN HO LEE, SEUNG HO AN, YANG SOO AHN, KYOUNG EOB CHOI, ROK LIM YUN, CHUN SEON LYU, YEO HONG YOON, JE HAK KIM, SUNG YONG PARK, SUNG KI CHO, CHOONG SUP KIM
Format Patent
LanguageEnglish
Published 12.01.1993
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel semi-synthetic cephalosporin derivatives having a fused pyridiniummethyl at 3-position of the cephem nucleus, pharmaceutically acceptable salts, physiologically hydrolizable esters or solvates thereof are disclosed. Also disclosed is a process for preparing the cephalosporin derivatives which comprises introducing a fused pyridiniummethyl substituent at 3-position of 7- beta -[(Z)-2-(2-aminothiazol-4yl) -2-methoxyiminoacetamino]-3-cephem-carboxylic acid derivatives. The compounds of the present invention show potent antibacterial activities and a broad spectrum against both gram-positive and gram-negative bacterial.
Bibliography:Application Number: AU19920017861