Novel pyrimidine-5-carboxamide derivatives

• Main Authors: RYO NAITO, SOUICHIROU KAWAZOE, AKIKO ORITA, AKIRA TOYOSHIMA, HIROYUKI HISAMICHI, ATSUSHI ICHIKAWA, EI-ICHI NAKAI, KAZUHITO TANABE, MAKOTO TAKEUCHI
• Format: Patent
• Language: English
• Published: 05.07.1999
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Pyrimidine-5-carboxamide derivatives represented by a general formula (I) or salts thereof Äwherein each symbol has the following meaning; X: O, S, NR , CO, NR CO, CONR , C=N-OR or a bond, Y: a lower alkylene group which may be substituted by OR or -NHR , or a bond, Z: O, NR or a bond, A: H, or a lower alkyl which may have a substituent, a -CO-lower alkyl which may have a substituent, an aryl which may have a substituent, a heteroaryl which may have a substituent, a cycloalkyl which may have a substituent or a nitrogen-containing saturated heterocyclic group which may have a substituent, B: an aryl which may have a substituent or a heteroaryl group which may have a substituent, R , R : H, a lower alkyl or a -CO-lower alkyl groupÜ.