Cyclopentyl tachykinin receptor antagonists

The present invention is directed to certain novel compounds represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein R , R , R , R , R , R , R , A, Q, W, X, Y, Z and n are defined herein. The invention is also concerned with pharmaceutical formulations comprising...

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Bibliographic Details
Main Authors LAURA C. MEURER, PHILIPPE L. DURETTE, EDWARD HOLSON, PAUL E. FINKE, SANDER G. MILLS, IHOR KOPKA, ALBERT ROBICHAUD, PING CHEN, JEFFERY HALE, MALCOM MACCOSS, CHARLES G CALDWELL
Format Patent
LanguageEnglish
Published 07.05.1997
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:The present invention is directed to certain novel compounds represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein R , R , R , R , R , R , R , A, Q, W, X, Y, Z and n are defined herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulation in the treatment of certain disorders. The compounds of this invention are tachykinin receptor antagonists and are useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis.
Bibliography:Application Number: AU1049797