PLATINKOMPLEXE UND ANTITUMORMITTEL, DIE DIESE ALS WIRKSTOFFE ENTHALTEN

Novel platinum complexes of the formula: wherein R and R are identical or different lower alkyl groups, or R and R taken together form a -(CH2)m- bridge, and m is an integer from 2 to 5, and antitumor agents comprising the compounds (I) are disclosed, which are effective against cisplatin-resistant...

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Bibliographic Details
Main Authors TOTANI, TETSUSHI, SHIRATORI, OSAMU, MURAOKA, YOSHIHIRO
Format Patent
LanguageEnglish
German
Published 15.01.1994
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel platinum complexes of the formula: wherein R and R are identical or different lower alkyl groups, or R and R taken together form a -(CH2)m- bridge, and m is an integer from 2 to 5, and antitumor agents comprising the compounds (I) are disclosed, which are effective against cisplatin-resistant ascitic murine leukemia, murine leukemia, and solid tumors with only slight hemotoxicity and nephrotoxicity.
Bibliography:Application Number: AT19900106012T