SULFONYLCARBOXAMIDE

There are disclosed compounds of formula (I), wherein W is -O-, -S-, alpha or -CH2-; X is O, S, NR , CH=CH, CH=N or N=CH; Y is -CH2O-, -CH2S-, beta , -O-, -S-, psi , delta , epsilon or phi ; R is lower alkyl, perfluoroloweralkyl or phenyl substituted with R ; R is hydrogen or lower alkyl; R , R and...

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Bibliographic Details
Main Authors KREFT, ANTHONY, F. III, KUBRAK, DENNIS, M, MUSSER, JOHN, H
Format Patent
LanguageEnglish
German
Published 15.01.1992
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:There are disclosed compounds of formula (I), wherein W is -O-, -S-, alpha or -CH2-; X is O, S, NR , CH=CH, CH=N or N=CH; Y is -CH2O-, -CH2S-, beta , -O-, -S-, psi , delta , epsilon or phi ; R is lower alkyl, perfluoroloweralkyl or phenyl substituted with R ; R is hydrogen or lower alkyl; R , R and R are each independently hydrogen, lower alkyl, nitro, trifluoromethyl, halo, lower alkoxy, lower alkoxycarbonyl or lower alkanoyloxy; n is 0-1; m is 0-10; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions.
Bibliography:Application Number: AT19880903531T