ANTIKÖRPERABHÄNGIGER ZELLULÄRER ZYTOTOXIZITÄTSTEST

Methods for detecting antibody dependent cellular cytotoxicity (ADCC) are described herein. The methods are label-free, and can be performed in real time on adherent cells. The methods can include, for example, (a) monitoring the impedance between electrodes on a non-conducting substrate that suppor...

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Bibliographic Details
Main Authors KUNICH, JOHN, LIU, CHENG
Format Patent
LanguageGerman
Published 15.08.2010
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Summary:Methods for detecting antibody dependent cellular cytotoxicity (ADCC) are described herein. The methods are label-free, and can be performed in real time on adherent cells. The methods can include, for example, (a) monitoring the impedance between electrodes on a non-conducting substrate that supports the growth of target cells in an assay medium; and (b) adding effector cells and an antibody that binds to the target cells to the assay medium; wherein any decrease in the impedance between the electrodes on the substrate following addition of the effector cells and the antibody is indicative of ADCC function having been effected in the assay medium.
Bibliography:Application Number: AT20070717805T