VERBINDUNGEN MIT AKTIVITÄT AN DER 11BETA- HYDROXASTEROIDDEHYDROGENASE

The use of substituted amides for modulating the activity of 11²-hydroxysteroid dehydrogenase type 1 (11²HSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the comp...

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Main Authors GUNDERTOFTE, ANETTE, KAMPEN, GITA CAMILLA TEJLGAARD, JORGENSEN, ANKER STEEN, ANDERSEN, HENRIK SUNE, KILBURN, JOHN PAUL, CHRISTENSEN, INGE THOGER
Format Patent
LanguageGerman
Published 15.05.2010
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The use of substituted amides for modulating the activity of 11²-hydroxysteroid dehydrogenase type 1 (11²HSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11²HSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.
Bibliography:Application Number: AT20070102177T