CHINOLINDERIVATE, SYNTHESEVERFAHREN UND DIESE DERIVATE ENTHALTENDE MEDIKAMENTE

The invention relates to derivatives corresponding to formula I: in which X is an alkyl-(CH2)n- chain with n=0, 1 or 2, or O or N, Z is an aromatic which may contain heteroatoms chosen from O, N or S, as substitutions for the carbon atoms constituting said aromatic ring, this ring being substituted...

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Main Authors BENARD, CHRISTOPHE, LE BRET, MARC, MOUSCADET, JEAN-FRANCOIS, DANET, MICHELE, D'ANGELO, JEAN, JANSON, LAURENCE, BAYLE, MARIE, ZOUHIRI, FATIMA, DESMA LE, DIDIER, LEH, HERVE, SUBRA, FREDERIC
Format Patent
LanguageGerman
Published 15.05.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to derivatives corresponding to formula I: in which X is an alkyl-(CH2)n- chain with n=0, 1 or 2, or O or N, Z is an aromatic which may contain heteroatoms chosen from O, N or S, as substitutions for the carbon atoms constituting said aromatic ring, this ring being substituted or otherwise with Rb, Rb represents 1 to 3 substituents chosen from -OH, -OR, -COOH, -COOR, -COH, -COR, -NH2, -NH(R), -NH(R,R'), -SH, -SR and CN, Ra is H or -(CH2)n'-Y, with n'=0, 1, 2 or 3 and Y and -CH3, -COOH, -COOR, -CN, -OH, -OR, SR, or an aryl group optionally substituted with Rb, R and R' represent a linear or branched alkyl chain of 1 to 4 C, and their pharmaceutically acceptable salts. Application as active ingredient of medicaments inhibiting retrovirus integrases.
Bibliography:Application Number: AT20020795314T