VERFAHREN FÜR DIE PHOTODYNAMISCHE INAKTIVIERUNG VON PATHOGENEN MIT ALA

• Main Authors: VIGNERON, CLAUDE, MARCHAND-ARVIER, MONIQUE, VERPOORT, THIERRY, MAURICE-DUELLI, AURORE, NOTET, VERONIQUE
• Format: Patent
• Language: German
• Published: 15.12.2008
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a method for inactivating pathogens, particularly viruses and bacteria in a biological fluid comprising blood cells. The method comprises the steps: preparation of, or placing of the fluid in a container, at least a part of the walls of which are transparent to radiation with a wavelength between 350 nm and 450 nm, introduction of the 5-aminolevulinic acid (ALA), or a derivative thereof into the fluid, such as to allow the transformation of the ALA into protoporphyrin IX, irradiation of the container with at least one radiation of wavelength between 350 nm and 450 nm such that, on activating the protoporphyrin IX, the pathogens are inactivated, whereby the fluid has the leukocytes removed prior to the introduction of the ALA.